Communication - Hampered by Alzheimer's

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Alzheimer's

 Marks of Alzheimer's Seen in Last Murdoch Novel
 Healthy Aging
03-07-03
NPR
Changing Face of Alzheimer's NPR Nov 03
Encarta online
Alheimers.org.uk
pbs.org: forgetting

Young Man, Old Body

BBC Radio 4, 9/03

LONI (neuro imaging)
 Learning to Speak Alzheimer's Oct 03
Talk of the nation

Parkinsons

Parkinson's Disease
Parkinson's Disease Society
Neurosurgery.org
Wikipedia

 Iris Murdoch (Movie)

Iris Murdoch 1919-1999

Internet Movie Database

Iris Murdoch resources

alternative movie:

A Beautiful Mind

M. Stotz on Murdoch

 

Neuro Sciences

Neuromarketing and Mind Machines
Neuromarketing overview
The Word Spy: Neuromarketing
Why We Prefer Pepsi and Drink Coke Anyway
Neuroscience for kids
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Alois Alzheimer

Medical Aspects Alzheimer Patients Case Study: Iris Murdoch

LONI

Charlton Heston

Medical Aspects

Alzheimer’s Disease, progressive brain disorder that causes a gradual and irreversible decline in memory, language skills, perception of time and space, and, eventually, the ability to care for oneself. First described by German psychiatrist Alois Alzheimer in 1906, Alzheimer’s disease was initially thought to be a rare condition affecting only young people, and was referred to as presenile dementia. Today late-onset Alzheimer’s disease is recognized as the most common cause of the loss of mental function in those aged 65 and over. Alzheimer’s in people in their 30s, 40s, and 50s, called early-onset Alzheimer’s disease, occurs much less frequently, accounting for less than 10 percent of the estimated 4 million Alzheimer’s cases in the United States.

Source: Encarta

Cloze exercise (htm with explanations) on Alzheimer's Disease:  [doc] [pdf]

TRACKING MEMORY'S DECLINE

Powerful imaging techniques can detect changes, over time, in parts of the human brain linked to Alzheimer's and related disorders.

Target Areas: Frontal, Parietal, Temporal Areas

Important centers for a variety of memory functions: verbal, visual, new memory, working memory, etc. PET scanners can detect levels of glucose metabolism in areas of the brain that are important for memory.

WSJ

1. The hippocampus - Deep inside the brain, the hippocampus is important for learning and short-term memory. Believed to be the site where short-term memory is converted to long-term for storage elsewhere in the brain. Repeated MRI scans over time can reveal volume loss.

2. Entorhinal cortex - Scientists believe that Alzheimer's dementia begins here. It's an area with direct connections to the hippocampus. Degeneration can interfere with the ability of the hippocampus to get information from the rest of the brain. This region begins to atrophy or shrink, probably 10 to 20 years before any visible signs or symptoms appear.

Sources: National Institute on Aging; New York University School of Medicine (PET, MRI images)

tau and neurofibrillary tangles

source

entorhinal cortex + hippocampus

source

neuron = nerve cell

source

synapse + neurotransmitter

Famous Alzheimer's Patients

List of famous Alzheimer patients: Ronald Reagan, Rita Hayworth, Iris Murdoch, Winston Churchill, Ralph Waldo Emerson, Henry Ford, Maurice Ravel ..... (read more)

Did you know that Alzheimer’s disease can affect even the rich and famous?

Former President of USA, Mr Ronald Reagan, has Alzheimer’s disease.

Many myths and misconceptions prevail about Alzheimer’s disease. It is not only the common man but some physicians too who lack a proper understanding of this disease.

http://w3.whosea.org/alzheimer/myths.htm

Why We Dig Charlton Heston

Charlton Heston, simply put, is the greatest leading man in film history. The charisma, dignity, grace and strength he conveyed on the silver screen define what it is to be a leading man. Heston has screen presence in biblical proportions, and its appropriate that his prime came about while Hollywood had an obsession with making epics -- the gravitas he embued in his characters made him a perfect fit in Tinsel Town's Golden Era. There has never been anyone else quite like him before or since and there may never be.

Charlton Heston Online Shrine

Case Study: Iris Murdoch (Alzheimer's in fiction)

Writer Iris Murdoch has Alzheimer's disease LONDON (AP) February 4, 1997

When the acclaimed novelist and philosopher Dame Iris Murdoch became vague and forgetful, she attributed it to writer's block. Doctors have determined the cause is Alzheimer's disease.

A woman who once was able to assemble an entire novel in her head can no longer remember the titles of her books, said John Bayley, the literary critic and professor of English who married Murdoch in 1956.

"Iris has Alzheimer's. There is no doubt about it," Bayley told the Daily Telegraph.

"Being a very intelligent woman, she has managed to cover it up for some time -- there is a facade of social graces. But as soon as you scratch the surface, she is profoundly amnesic."

The diagnosis was verified by Dr. John Hodges, a neurologist who has visited 77-year-old Murdoch twice at her home in Oxford, the newspaper said.

Bayley said Murdoch first became forgetful about four years ago, losing her way on a trip to London to visit friends.

Six months ago, the novelist likened her recent inability to write to being in "a hard, dark place," from which was trying to escape.

"Now, I'm afraid I am waiting in vain," the Daily Telegraph quoted her as saying. "Perhaps I had better find some other kind of job."

Bayley, 71, told newspaper: "One of the tragedies is that she has forgotten so much about her own life and cannot tell you the names of any of the books she has written. She has a striking language problem."

Born in Dublin and educated at Oxford and Cambridge universities, Murdoch has written 26 novels -- the first, Under the Net, in 1954. Described as psychological detective stories, they depict complicated sexual relationships, usually between professionals, and her plots often contain a touch of the comic, the macabre, or the weird.

Her 1961 novel, A Severed Head, was dramatized by the writer J.B. Priestley; The Sea, The Sea, a searing story about a theatre director and his childhood love, won the Booker Prize in 1978.

Murdoch, who has also taught and written about philosophy, was made a Dame of the British Empire in 1987.

Professor John Bayley announces Alzheimer's Society - Iris Murdoch Research Fellowship 20 Nov 2000

Professor John Bayley, husband of the late Dame Iris Murdoch, will today announce the setting up of an Alzheimer's Society - Iris Murdoch Research Fellowship to promote new research into communication by and with people with dementia. Opening the 1st International Quality Research in Dementia Conference in London, Professor Bayley will say:

"It is fitting and appropriate that Iris Murdoch's name should be leant to research that will further our understanding of the communication difficulties faced by people with dementia and those close to them. I hope investigations in this under-researched field will lead to tangible improvements in the way we communicate with those suffering from this devastating disease." People with dementia face increasing difficulties in understanding what is said or what is going on around them as their disease progresses. They gradually lose their speech, endlessly repeat the same words or cry out from time to time. What is sometimes seen as challenging behaviour exhibited by people with dementia is often an attempt by the person to communicate. Very little is known about the way in which dementia affects the language centres of the brain and the Alzheimer's Society - Iris Murdoch Research Fellowship will focus on this area.

Applications for the Alzheimer's Society - Iris Murdoch Research Fellowship will be invited in due course. It is expected that the Fellowship will be for three years with funding up to Ł150,000.

The Society's director of research, Dr Richard Harvey, commented:

"People with dementia should be encouraged to communicate in whatever way seems most appropriate in order to help them preserve their own sense of identity and improve their quality of life. Topics for the fellowship might include the psycho linguistics of dementia or the use of non-verbal communication with people with dementia. This research fellowship will therefore play an invaluable role in furthering our understanding in this field and in helping us to better communicate with people with dementia in the future." Over 500 scientists and carers attending the four-day Quality Research in Dementia conference will hear papers presenting new and recent research on the causes of dementia, genetics, current and future treatments and quality of care.

Iris (2001/I)  (IMDb)

Directed by: Richard Eyre

Writing credits: John Bayley (books) Richard Eyre (screenplay) ... (more)

Tagline: Her greatest talent was for life

Plot Outline: True story of the lifelong romance between novelist Iris Murdoch and her husband John Bayley, from their student days through her battle with Alzheimer's disease. (more) (view trailer)

User Comments: Over-rated bio-pic of famous writer (more)

User Rating: 7.2/10 (2,549 votes)

Cast :

 Judi Dench-Iris Murdoch Jim Broadbent-John Bayley Kate Winslet-Young Iris Hugh Bonneville-Young John
BBC Obituary,  9 February 1999  

 

Work Sheets

Communication Skills

pdf / htm

annotated extract from Iris pdf / htm
BBC Obituary

Alzheimer's - cloze exercise

Two Case Studies

Alzheimer's disease

 

Stem cells